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CSA Working Groups and Research Projects

Completed Projects

Nutrition Related to Bone Health in Children
Within the framework of this project, an informational report was published with great success in 2001. Translated into some 20 languages, the report provided a succinct review of how diet, life styles and genetics affect bone development in young people

See report

Project Co-ordinator: J-P.Bonjour

EFFO Guidelines for Diagnosis and Management of Osteoporosis
The panel which edited this 1997 publication, Professors J.A. Kanis, P.D. Delmas, P. Burckhardt, C.Cooper, and D.Torgerson, believed that the guidelines were necessary to make it easier for primary care physicians to treat osteoporosis. The case finding strategy outlined in this document has formed the basis for practice guidelines adopted by the European Community as well as many countries around the world. The preamble to the publication notes: "Despite an increasing professional and public awareness of osteoporosis, the management of osteoporosis has been confined mainly to specialists. With the large number of affected individuals and the wider availability of diagnostic tools and proven therapies, there is a need for osteoporosis to be managed predominantly by the primary care physician."

  • Kanis, JA, Delmas, P, Burckhardt, P, Cooper, C, Torgerson, D, on behalf of the EFFO (1997)
    Guidelines for diagnosis and management of osteoporosis.
    Osteoporosis International 7; 390-406.
  • Kanis JA, Gluer C-C for the Committee of Scientific Advisors, International Osteoporosis Foundatation (2000) An update on the diagnosis and assessment of osteoporosis with densitometry.
    Osteoporosis International; 11: 192-202.

EFFO, and later IOF, also provided standards for diagnosis and management in other documents:

  • Kanis, JA, Devogelaer, J-P, Gennari, C (1996)
    Practical guide for the use of bone mineral measurements in the assessment and treatment of osteoporosis. A position paper of the European Foundation for osteoporosis and bone disease. Osteoporosis International 6, 256-261
  • Kanis, JA, Devogelaer, JB, Gennari, C (1996)
    Guia practica para el empleo de las medidas de contenido mineral oseo en la evaluacion del tratamiento de la osteoporosis: un informe de la European Foundation for Osteoporosis and Bone Disease.
    Revista Espanola de Enfermedades Metabolicas Oseas 5; 178-181.

Guidelines for Clinical Trials in Osteoporosis
Published in 1991, these were the first guidelines published in this area in Europe and provided a forerunner for guidelines produced by government agencies and non-govermental organizations:

  • Kanis J, Geusens P and Christiansen C on behalf of the Working Party of the Foundation. 'Guidelines for clinical trials in osteoporosis. A position paper of the European Foundation For Osteoporosis and Bone Disease.' Osteoporosis Int (1991) 1:182-188

The WHO guidelines were initiated following a consultation between the EFFO and WHO:

  • World Health Organisation (1998)
    Guidelines for preclinical evaluation and clinical trials in osteoporosis.
    WHO, Geneve

The Mediterranean Osteoporosis Study (MEDOS)
The first scientific activity of EFFO was the three-part MEDOS project, which was initiated in 1986 shortly before EFFO's bylaws were registered. Gathering existing data on hip fractures, a prospective study of hip fracture projected incidence in participating centres, and a case control study to identify risk factors in men and women, MEDOS has resulted in 20 to 30 scientific publications. Six countries participated: France, Greece, Italy, Portugal, Spain and Turkey.

See list of publications (PDF,72 KB)

Resource Document/position paper on biochemical bone markers
Biochemical markers of bone turnover have been developed over the past 20 years which are more specific for bone tissue than conventional markers. However the clinical use of these newer bone markers in the management of the individual patient has not yet been clearly defined and is still subject to debate. For this reason an expert group of IOF's Committee of Scientific Advisors was commissioned to summarise the available data and make practical recommendations, The use of biochemical markers of bone turnover in the management of post-menopausal osteoporosis, which were published in Osteoporosis International vol.11 supplement 6, 2000.

Download paper (PDF,175 KB)

Systematic Review of Health State Utility Values for Osteoporosis and its Treatment
This project involves a systematic review of studies on the cost-effectiveness of health-care interventions for osteoporosis. There is a need to review data because studies in the past two decades have shown a wide range of variations in health state values thus leading to a considerable amount of uncertainty regarding which set of values to use in an economic model. The main goal is to come up with a standard set of values to show cost effectiveness and treatment thresholds.

Project Co-ordinator: J.A. Kanis


  • Brazier J, Green C, Kanis JA, on behalf of the Committee of Scientific Advisors, International Osteoporosis Foundation (2002)
    A systematic review of health state utility values for osteoporosis related conditions (PDF, 102 KB)
    Osteoporosis International 13; 768-776
  • Zethraeus N, Sendrine B, Caulin F, Corcaud S, Gathon HJ, Johnell O, Haim M, Jonsson B, Kanis JA, Tsouderos Y, Reginster J-Y (2002)
    Models for assessing the cost-effectiveness of the treatment and prevention of osteoporosis.
    Osteoporosis Int 13; 841-857.
  • Kanis JA, Jonsson B (2002)
    Economic evaluation of interventions for osteoporosis.
    Osteoporosis International 13; 765-767.

CSA Working Groups, Research Projects and Publications
Ongoing projects
Multinational Partnership Initatives

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