IOF - International Osteoporosis Foundation

Left Navigation
For Health Professionals

Please note: in order to open PDF files you need Acrobat Reader (free software).

Get Acrobat Reader

Are you having trouble with PDF files? Click here.

Top Navigation Homepage Search Sitemap Contact IOF Members Only

Publications related to IOF Working Groups and Research Projects

1. Biochemical Markers
2. Diagnosis/Densitometry
3. Epidemiology and Costs
4. European Prospective Osteoporosis Study (EPOS/EVOS)
5. Guidelines and Recommendations
6. Osteoporosis in Men
7. Quality of Life
8. Treatment/Vitamin D
9. WHO Collaboration

Also see general and advocacy-related Reviews and Editorials

1. Biochemical Markers

Bruyere O, Collette J, Delmas P, Rouillon A, Roux C, Seidel L, Richy F, Reginster JY
'Interest of biochemical markers of bone turnover for long-term prediction of new vertebral fracture in postmenopausal osteoporotic women.'
Maturitas. 2003 Apr 25;44 (4):259-65.

Szulc P, Delmas PD.
'Biochemical markers of bone turnover in men.'
Calcif Tissue Int. 2001 Oct;69 (4):229-34. Review.

Delmas PD.
'Standardization of bone marker nomenclature.'
Clin Chem. 2001 Aug;47(8):1497.

Delmas PD; Committee of Scientific Advisors of the International Osteoporosis Foundation.
'Bone marker nomenclature.'
Bone. 2001 Jun;28(6):575-6.

P.D. Delmas, R. Eastell, P. Garnero, M.J. Seibel, and J. Stepan for the Committee of Scientific Advisors
'The Use of Biochemical Markers of Bone Turnover in Osteoporosis.'
Osteoporosis Int. 2000 Suppl. 6:S2-17 (PDF, 175 KB)

Page Top

2. Diagnosis/Densitometry

Kanis JA, Black D, Cooper C, Dargent P, Dawson-Hughes B, De Laet C, Delmas P, Eisman J, Johnell O, Jonsson B, Melton L, Oden A, Papapoulos S, Pols H, Rizzoli R, Silman A, Tenenhouse A; International Osteoporosis Foundation; National Osteoporosis Foundation.
'A new approach to the development of assessment guidelines for osteoporosis.'
Osteoporos Int. 2002 Jul;13 (7):527-36. (PDF)

Kanis JA.
'Diagnosis of osteoporosis and assessment of fracture risk.'
Lancet. 2002 Jun 1;359(9321):1929-36. Review.

Lau EM., Cooper C.
'Risk factors for osteoporosis in Europe.'
J Bone Miner Metab. 2001;19(3):142-5. Review

Kanis JA, Gl¸er CC, for the Committee of Scientific Advisors IOF. 2000
'An update on the diagnosis and assessment of osteoporosis with densitometry.'
Osteoporosis Int 11:192-202. (PDF, 115 KB)

Kanis JA.
'An update on the diagnosis of osteoporosis.'
Curr Rheumatol Rep. 2000 Feb;2(1):62-6. Review.

Kanis J., Delmas P. Bruckhardt P, Cooper C Torgerson D on behalf of the European Foundation for Osteoporosis.
'Guidelines for diagnosis and management of osteoporosis', European Foundation For Osteoporosis and Bone Disease
Osteoporosis Int. (1997) 7:390-406

Kanis J, Devogelaer J-P, Gennari C on behalf of the Scientific Advisory Board and the Board of National Societies of the European Foundation For Osteoporosis and Bone Disease.
'Bone Density Measurement in the Assessment and Treatment of Osteoporosis: Practical Guidelines.'
Blackwell Healthcare Ltd. (1997) ISBN 0-632-04959-6

Gluer CC.
'Quantitative ultrasound techniques for the assessment of osteoporosis: expert agreement on current status.'
The International Quantitative Ultrasound Consensus Group.
J Bone Miner Res. 1997 Aug;12(8):1280-8. Review.

Kanis J, Devogelaer J-P and Gennari C on behalf of the Scientific Advisory Board and the Board of National Societies.
'Practical guide for the use of bone mineral measurements in the assessment and treatment of osteoporosis: A position paper of the European Foundation For Osteoporosis and Bone Disease.'
Osteoporosis Int (1996) 6:256-261

Kanis JA, Melton LJ3rd, Christiansen C, Johnston CC, Khalteav N.
'Perspectives. The diagnosis of osteoporosis'.
J. Bone Mineral Res, 1994, 9:1137-1141

'Availability and reimbursement of bone mineral density measurement in European countries. An EFFO Report.'
Osteoporosis Int .1997, 7: 00-00

'Postmenopausal Osteoporosis. A handbook for the medical profession (The Silent Epidemic).'
C Christiansen and BJ Riis,
printed in 1990, pp. 7-80

Page Top

3. Epidemiology and Costs

Note: list of publications arising from the Mediterranean Osteoporosis Study (MEDOS) are available here (PDF)

Kanis JA, Oden A, Johnell O, De Laet C, Jonsson B, Oglesby AK.
'The components of excess mortality after hip fracture.'
Bone. 2003 May;32(5):468-73.

Melton LJ 3rd, Gabriel SE, Crowson CS, Tosteson AN, Johnell O, Kanis JA.
'Cost-equivalence of different osteoporotic fractures.'
Osteoporos Int. 2003 Apr 1

Szulc P, Munoz F, Marchand F, Sornay-Rendu E, Delmas PD.
'Similar prevalence of vertebral fractures despite different approaches to define reference data.'
Bone. 2003 Apr;32 (4):441-8.

Kanis JA, Brazier JE, Stevenson M, Calvert NW, Lloyd Jones M.
'Treatment of established osteoporosis: a systematic review and cost-utility analysis.'
Health Technol Assess. 2002;6(29):1-146. Review.

J. E. Brazier, C. Green and J. A. Kanis on behalf of the Committee of Scientic Advisors, International Osteoporosis Foundation.
'A Systematic Review of Health State Utility Values for Osteoporosis- Related Conditions.'
Osteoporos Int 2002 13:768-776 (PDF)

Zethraeus N, Ben Sedrine W, Caulin F, Corcaud S, Gathon HJ, Haim M, Johnell O, Jonsson B, Kanis JA, Tsouderos Y, Reginster JY
'Models for assessing the cost-effectiveness of the treatment and prevention of osteoporosis.'
Osteoporos Int. 2002 Nov;13 (11):841-57. Review. (PDF)

Kanis JA, Jonsson B.
'Economic evaluation of interventions for osteoporosis.'
Osteoporos Int. 2002 Oct;13 (10):765-7. (PDF)

Kanis JA, Johnell O, Oden A, De Laet C, Oglesby A, Jonsson B.
'Intervention thresholds for osteoporosis.'
Bone. 2002 Jul;31 (1):26-31.

Kanis JA, Johnell O, De Laet C, Jonsson B, Oden A, Ogelsby AK.
'International variations in hip fracture probabilities: implications for risk assessment.'
J Bone Miner Res. 2002 Jul;17 (7):1237-44.

Johnell O, Oden A, De Laet C, Garnero P, Delmas PD, Kanis JA.
'Biochemical indices of bone turnover and the assessment of fracture probability.'
Osteoporos Int. 2002 Jul;13 (7):523-6.

Kanis JA, Oden A, Johnell O, Caulin F, Bone H, Alexandre JM, Abadie E, Lekkerkerker F.
'Uncertain future of trials in osteoporosis.'
Osteoporos Int. 2002;13(6):443-9. Review.

Ben Sedrine W, Broers P, Devogelaer JP, Depresseux G, Kaufman JM, Goemaere S, Reginster JY.
'Interest of a prescreening questionnaire to reduce the cost of bone densitometry.'
Osteoporos Int. 2002 May;13 (5):434-42. (PDF)

Reginster JY, Khaltaev NG.
'Introduction and WHO perspective on the global burden of musculoskeletal conditions.'
Rheumatology (Oxford). 2002 Apr; 41 Supp 1:1-2.

Kanis JA, Johnell O, Oden A, De Laet C, Jonsson B, Dawson A.
'Ten-year risk of osteoporotic fracture and the effect of risk factors on screening strategies.'
Bone. 2002 Jan;30 (1):251-8.

Ben Sedrine W, Devogelaer JP, Kaufman JM, Goemaere S, Depresseux G, Zegels B, Deroisy R, Reginster JY.
'Evaluation of the simple calculated osteoporosis risk estimation (SCORE) in a sample of white women from Belgium.'
Bone. 2001 Oct;29 (4):374-80.

Kanis JA, Johnell O, Oden A, Dawson A, De Laet C, Jonsson B.
'Ten year probabilities of osteoporotic fractures according to BMD and diagnostic thresholds.'
Osteoporos Int. 2001 Dec;12 (12):989-95.

Kanis JA, Oden A, Johnell O, Jonsson B, de Laet C, Dawson A.
'The burden of osteoporotic fractures: a method for setting intervention thresholds.'
Osteoporos Int. 2001;12 (5):417-27.

Kanis JA, Dawson A, Oden A, Johnell O, de Laet C, Jonsson B.
'Cost-effectiveness of preventing hip fracture in the general female population.'
Osteoporos Int. 2001;12(5):356-61.

Johnell O, Oden A, Caulin F, Kanis JA.
'Acute and long-term increase in fracture risk after hospitalization for vertebral fracture.'
Osteoporos Int. 2001;12 (3):207-14.

Kanis JA, Johnell O, Oden A, Sembo I, Redlund-Johnell I, Dawson A, De Laet C, Jonsson B.
'Long-term risk of osteoporotic fracture in Malmo.'
Osteoporos Int. 2000;11(8):669-74.

Kanis JA, Johnell O, Oden A, Jonsson B, De Laet C, Dawson A.
'Risk of hip fracture according to the World Health Organization criteria for osteopenia and osteoporosis.'
Bone. 2000 Nov;27(5):585-90.

Johnell O, Gullberg B and Kanis J.
'The hospital burden of vertebral fracture in Europe: A study of national register sources.'
Osteoporosis Int 1997 7:138-141

Ranstam J, Elffors L, Kanis J.
'A Mental – functional Risk Score for Prediction of Hip Fracture.'
Age and Ageing 1996, 25, 439-442

Ranstam J. & Kanis J.A.
'Influence of age and body mass on the effects of vitamin D on hip fracture risk.'
Osteoporosis Int. 1995, 5: 450 – 454

Johnell O, Gullberg B, Allander E, Kanis J and the MEDOS Study Group.
'The apparent incidence of hip fracture in Europe: A study of national register sources.'
Osteoporosis Int 1992 , 2:298-302

Kanis J, Johnell O, Gullberg B, Allander E, Dilsen G, Gennari C, Lopes Vaz A, Lyritis G, Mazzuoli G, Miravet L, Passeri M, Perez Cano R, Rapado A, Ribot C.
'Evidence for efficacy of drugs affecting bone metabolism in preventing hip fracture.'
British Medical Journal 1992, 305, 1124 – 1128

Page Top

4. European Prospective Osteoporosis Study EPOS/EVOS

A complete list of EPOS/EVOS publications is available online at:
http://www.srl.cam.ac.uk/epos/epospublications.html

Roy DK, O'Neill TW, Finn JD, Lunt M, Silman AJ, Felsenberg D, Armbrecht G, Banzer D, Benevolenskaya LI, Bhalla A, Bruges Armas J, Cannata JB, Cooper C, Dequeker J, Diaz MN, Eastell R, Yershova OB, Felsch B, Gowin W, Havelka S, Hoszowski K, Ismail AA, Jajic I, Janott I, Johnell O, Kanis JA, Kragl G, Lopez Vaz A, Lorenc R, Lyritis G, Masaryk P, Matthis C, Miazgowski T, Gennari C, Pols HA, Poor G, Raspe HH, Reid DM, Reisinger W, Scheidt-Nave C, Stepan JJ, Todd CJ, Weber K, Woolf AD, Reeve J; European Prospective Osteoporosis Study (EPOS).
'Determinants of incident vertebral fracture in men and women: results from the European Prospective Osteoporosis Study (EPOS).'
Osteoporos Int. 2003 Jan;14 (1):19-26.

Hasserius R, Karlsson MK, Nilsson BE, Redlund-Johnell I, Johnell O; European Vertebral Osteoporosis Study.
'Prevalent vertebral deformities predict increased mortality and increased fracture rate in both men and women: a 10-year population-based study of 598 individuals from the Swedish cohort in the European Vertebral Osteoporosis Study.'
Osteoporos Int. 2003 Jan;14 (1):61-8.

Johnell, O.
'Determinants of incident vertebral fracture in men and women: results from the European Prospective Osteoporosis Study (EPOS).'
Osteoporos Int. 2003 Jan;14 (1):19-26.

Lunt M, Ismail AA, Felsenberg D, Cooper C, Kanis JA, Reeve J, Silman AJ, O'Neill TW; European Prospective Osteoporosis Study Group.
'Defining incident vertebral deformities in population studies: a comparison of morphometric criteria.'
Osteoporos Int. 2002 Oct;13 (10):809-15.

Vergnaud P, Lunt M, Scheidt-Nave C, Poor G, Gennari C, Hoszowski K, Vaz AL, Reid DM, Benevolenskaya L, Grazio S, Weber K, Miazgowski T, Stepan JJ, Masaryk P, Galan F, Armas JB, Lorenc R, Havelka S, Perez Cano R, Seibel M, Armbrecht G, Kaptoge S, O'Neill TW, Silman AJ, Felsenberg D, Reeve J, Delmas PD.
'Is the predictive power of previous fractures for new spine and non-spine fractures associated with biochemical evidence of altered bone remodelling? The EPOS study. European Prospective Osteoporosis Study.'
Clin Chim Acta. 2002 Aug;322(1-2):121-32.

Hasserius R, Karlsson MK, Nilsson BE, Redlund-Johnell I, Johnell O.
'Non-participants differ from participants as regards risk factors for vertebral deformities: a source of misinterpretation in the European Vertebral Osteoporosis Study.'
Acta Orthop Scand. 2002 Aug;73 (4):451-4.

Ismail AA, et al.
'Incidence of limb fracture across Europe: results from the European Prospective Osteoporosis Study (EPOS).'
Osteoporos Int. 2002 Jul;13 (7):565-71.

Ismail AA, Cockerill W, Cooper C, Finn JD, Abendroth K, Parisi G, Banzer D, Benevolenskaya LI, Bhalla AK, Armas JB, Cannata JB, Delmas PD, Dequeker J, Dilsen G, Eastell R, Ershova O, Falch JA, Felsch B, Havelka S, Hoszowski K, Jajic I, Kragl U, Johnell O, Lopez Vaz A, Lorenc R, Yriti GL, Marchand F, Masary P, Matthis C, Miazgowski T, Pols HA, Poor G, Rapado A, Raspe HH, Reid DM, Reisinger W, Janott J, Scheidt-Nave C, Stepan J, Todd C, Weber K, Woolf AD, Ambrecht G, Gowin W, Felsenberg D, Lunt M, Kanis JA, Reeve J, Silman AJ, O'Neill TW.
'Prevalent vertebral deformity predicts incident hip though not distal forearm fracture: results from the European Prospective Osteoporosis Study.'
Osteoporos Int. 2001;12 (2):85-90.

O'Neill T, Silman A, Naves Diaz M, Cooper C, Kanis J, Felsenberg D and the European Vertebral Osteoporosis Study Group.
'Influence of hormonal and reproductive factors on the risk of vertebral deformity in European women.'
Osteoporosis Int 1997 7:72-78

Naves Diaz M, O'Neill T, Silman A and the European Vertebral Osteoporosis Study Group.
'The influence of alcohol consumption on the risk of vertebral deformity.'
Osteoporosis Int 1997 7:65-71

Page Top

5.Guidelines and Recommendations

ML Bouxsein and O. Johnell.
Advisory statement 'Recommendations for enhancing the care of patients with fragility fractures' (publication to follow)

Olof Johnell, John Kaufman, Steve Cummings, Joseph Lane, Mary Bouxsein. 'Recommendations for Care of the Osteoporotic Fracture Patient to Reduce the Risk of Future Fracture' (publication to follow)

Kanis JA, Black D, Cooper C, Dargent P, Dawson-Hughes B, De Laet C, Delmas P, Eisman J, Johnell O, Jonsson B, Melton L, Oden A, Papapoulos S, Pols H, Rizzoli R, Silman A, Tenenhouse A; International Osteoporosis Foundation; National Osteoporosis Foundation.
'A new approach to the development of assessment guidelines for osteoporosis.'
Osteoporos Int. 2002 Jul;13 (7):527-36.

Johnell O, Kannus P, Obrant KJ, Jarvinen M, Parkkari J; Nordic Orthopedic Federation.
'Management of the patient after an osteoporotic fracture: Guidelines for orthopedic surgeons--consensus conference on Treatment of Osteoporosis for Orthopedic Surgeons'
Nordic Orthopedic Federation, Tampere, Finland 2000.

Kanis JA, Torgerson D, Cooper C
'Comparison of the European and USA practice guidelines for Osteoporosis.'
Trends Endocrinol Metab. 2000 Jan-Feb;11 (1):28-32.

'Guidelines for preclinical evaluation and clinical trials in osteoporosis', a collaboration between the WHO and EFFO.
WHO, Geneve 1998 (PDF, 970 KB)

Kanis J., Delmas P. Bruckhardt P, Cooper C Torgerson D on behalf of the European Foundation for Osteoporosis.
'Guidelines for diagnosis and management of osteoporosis',
European Foundation For Osteoporosis and Bone Disease: Osteoporosis Int. 1997 7:390-406

Kanis J, Devogelaer J-P, Gennari C on behalf of the Scientific Advisory Board and the Board of National Societies of the European Foundation For Osteoporosis and Bone Disease.
'Bone Density Measurement in the Assessment and Treatment of Osteoporosis: Practical Guidelines.'
Blackwell Healthcare Ltd. 1997 ISBN 0-632-04959-6

Kanis J, Devogelaer J-P and Gennari C on behalf of the Scientific Advisory Board and the Board of National Societies.
'Practical guide for the use of bone mineral measurements in the assessment and treatment of osteoporosis: A position paper of the European Foundation For Osteoporosis and Bone Disease.'
Osteoporosis Int 1996 6:256-261

Kanis J, Geusens P and Christiansen C on behalf of the Working Party of the Foundation.
'Guidelines for clinical trials in osteoporosis. A position paper of the European Foundation For Osteoporosis and Bone Disease.'
Osteoporosis Int 1991 1:182-188

Page Top

6. Osteoporosis in Men

Kanis JA, Johnell O, Oden A, De Laet C, Mellstrom D.
'Diagnosis of osteoporosis and fracture threshold in men.'
Calcif Tissue Int. 2001 Oct;69(4):218-21. Review.

Johnell O, Kanis J, Gullberg G.
'Mortality, morbidity, and assessment of fracture risk in male osteoporosis.'
Calcif Tissue Int. 2001 Oct;69(4):182-4. Review.

Goemaere S, Van Pottelbergh I, Zmierczak H, Toye K, Daems M, Demuynck R, Myny H, De Bacquer D, Kaufman JM.
'Inverse association between bone turnover rate and bone mineral density in community-dwelling men >70 years of age: no major role of sex steroid status.'
Bone. 2001 Sep;29(3):286-91.

Szulc P, Delmas PD.
'Biochemical markers of bone turnover in men.'
Calcif Tissue Int. 2001 Oct;69 (4):229-34. Review.

Szulc P, Garnero P, Munoz F, Marchand F, Delmas PD.
'Cross-sectional evaluation of bone metabolism in men.'
J Bone Miner Res. 2001 Sep;16 (9):1642-50.

Szulc P, Munoz F, Marchand F, Delmas PD.
'Semiquantitative evaluation of prevalent vertebral deformities in men and their relationship with osteoporosis: the MINOS study.'
Osteoporos Int. 2001;12 (4):302-10.

Kaufman JM, Johnell O, Abadie E, Adami S, Audran M, Avouac B, Sedrine WB, Calvo G, Devogelaer JP, Fuchs V, Kreutz G, Nilsson P, Pols H, Ringe J, Van Haelst L, Reginster JY.
'Background for studies on the treatment of male osteoporosis: state of the art.'
Ann Rheum Dis. 2000 Oct;59 (10):765-72. Review.

Page Top

7. Quality of Life

Note: Quality of Life Questionnaire, QUALEFFO-41, is available on the IOF website. Click here

Murrell P, Todd CJ, Martin A, Walton J, Lips P, Reeve J; Working Party for Quality of Life of the International Osteoporosis Foundation.
'Postal administration compared with nurse-supported administration of the QUALEFFO-41 in a population sample: comparison of results and assessment of psychometric properties.'
Osteoporos Int. 2001;12 (8):672-9.

Oleksik A, Lips P, Dawson A, Minshall ME, Shen W, Cooper C, Kanis J.
'Health-related quality of life in postmenopausal women with low BMD with or without prevalent vertebral fractures.'
J Bone Miner Res. 2000 Jul;15 (7):1384-92.

Lips P, Cooper C. Agnusdei D. Caulin F., Egger P, Johnell O, Kanis J, Kellingray S, Leplege A, Liberman U, McCloskey E, Minne H, Reeve J, Reginser J-Y, Scholz M, Todd C, de Vernejoul M, and I. Wiklund for the Working Party for Quality of Life of the European foundation for Osteoporosis.
'Quality of Life in Patients with Vertebral fractures; Validation of the Quality of Life Questionnaire of the European Foundation for Osteoporosis (QUALEFFO).'
Osteoporosis Int. 1999 2. 150-160

Lips P, Cooper C, Agnusdei D, Caulin F, Egger P, Johnell O, Kanis J, Liberman U, Minne H, Reeve J, Reginster J-Y, de Vernejoul M-C and Wiklund I.
'Quality of life as outcome in the treatment of osteoporosis: The development of a questionnaire for quality of life by the European Foundation For Osteoporosis.'
Osteoporosis Int (1997) 7:36-38

Pande KC, de Takats D, Kanis JA, Edwards V, Slade P, McCloskey EV.
'Development of a questionnaire (OPQ) to assess patient's knowledge about osteoporosis.'
Maturitas. 2000 Dec 29;37(2):75-81.

Lipps P, Cooper C. Agnusdei D. Caulin F., Egger P, Johnell O, Kanis J, Kellingray S, Leplege A, Liberman U, McCloskey E, Minne H, Reeve J, Reginser J-Y, Scholz M, Todd C, de Vernejoul M, and I. Wiklund for the Working Party for Quality of Life of the European foundation for Osteoporosis (now IOF).
'Quality of Life in Patients with Vertebral fractures; Validation of the Quality of Life Questionnaire of the European Foundation for Osteoporosis (QUALEFFO).'
Osteoporosis Int. 1999, 2. 150-160

Lips P, Cooper C, Agnusdei D, Caulin F, Egger P, Johnell O, Kanis J, Liberman U, Minne H, Reeve J, Reginster J-Y, de Vernejoul M-C and Wiklund I.
'Quality of life as outcome in the treatment of osteoporosis: The development of a questionnaire for quality of life by the European Foundation For Osteoporosis.'
Osteoporosis Int 1997, 7:36-38

Page Top

8. Treatment/Vitamin D

Delmas PD.
'Treatment of postmenopausal osteoporosis.'
Lancet. 2002 Jun 8;359(9322):2018-26. Review. (PDF)

Seeman E, Delmas PD.
'Reconstructing the skeleton with intermittent parathyroid hormone.'
Trends Endocrinol Metab. 2001 Sep;12(7):281-3. Review.

Lips P.
'Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications.'
Endocr Rev. 2001 Aug;22 (4):477-501. Review.

Page Top

9. WHO collaboration

'Guidelines for preclinical evaluation and clinical trials in osteoporosis', a collaboration between the WHO and EFFO.
1998 WHO, Geneve (PDF, 970 KB)

Kanis J and the WHO Study Group.
'Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: Synopsis of a WHO report.'
Osteoporosis Int 1994, 4:368-381

Report of a World Health Organisation study group.
'Assessment of fracture risk and its application to screening for postmenopausal osteoporosis.'
WHO Technical report series 843. 1994 ISBN 92 4 120843 0

Page Top


Homepage | Search | Sitemap | Contact IOF | Members Only

© 2003 International Osteoporosis Foundation:
About IOF | Legal Disclaimer